"Streptomyces avermitilis" mutants defective in methylation of avermectins
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چکیده
منابع مشابه
Avermectin B2 O-methyltransferase activity in "Streptomyces avermitilis" mutants that produce increased amounts of the avermectins.
The level of activity of avermectin B O-methyltransferase, the enzyme which catalyzes the conversion of avermectin B components to avermectin A components, was analyzed in a series of "Streptomyces avermitilis" mutants selected for increased production of the avermectins. In all of the mutants, increased avermectin production was accompanied by increased avermectin B O-methyltransferase activit...
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The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin, respectively. Avermectins produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic agents. Because wild-type strains only produce low levels of avermectins, much research effort has focused on improvements in avermectin production to meet the ever increasing demand for...
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Avermectins, a group of anthelmintic and insecticidal agents produced from Streptomyces avermitilis, are widely used in agricultural, veterinary, and medical fields. This study presents the first report on the potential of using nanosecond pulsed electric fields (nsPEFs) to improve avermectin production in S. avermitilis. The results of colony forming units showed that 20 pulses of nsPEFs at 10...
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Avermectin and its analogues are produced by the actinomycete Streptomyces avermitilis and are widely used in the field of animal health, agriculture, and human health. Here we have adopted a practical approach to successfully improve avermectin production in an industrial overproducer. Transcriptional levels of the wild-type strain and industrial overproducer in production cultures were monito...
متن کاملProduction of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis.
6,8a-deoxy derivatives of avermectins produced by a mutant strain of Streptomyces avermitilis K20571} derived by mutation from strain K2038 producing avermectins B l a and B2a selectively2). The parent strain K2038 carries two types of mutations, C-5 0-methylation (aveD) and the selective incorporation of branched-chain fatty acid into the avermectin molecule (X). The mutant strain K2057 has an...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1987
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.31.5.744